​論文一覧

2021

Research about Caloric Restriction, mitochondria and/or Aging

Individual evaluation of aging- and caloric restriction-related changes to distinct multimeric complexes of circulating adiponectin by

 immunoblotting

 Kobayashi, M., Nezu, Y., Itoh, M., Uchida, R., Arikawa, T., Otsubo, M., Nozaki, Y., Tagawa, R., Fujishima, Y., Maeda, N., Shimomura,

   I. & Higami, Y.

​ Exp Gerontol. 2022 Jul 164, 111821. doi: 10.1016/j.exger.2022.111821 (IF: 4.03 in 2021/22)

・Prolonged caloric restriction ameliorates age-related atrophy in slow and fast muscle fibers of rat soleus muscle.

 Mizunoe Y, Kobayashi M, Saito H, Goto A, Migitaka R, Miura K, Okita N, Sudo Y, Tagawa R, Yoshida M, Umemori A, Nakagawa Y, Shimano H,  Higami Y.

 Exp Gerontol. 2021 Aug 17;154:111519. doi: 10.1016/j.exger.2021.111519. Online ahead of print. (IF: 3.376 in 2019/20)

・Contribution of PGC-1α to Obesity- and Caloric Restriction-Related Physiological Changes in White Adipose Tissue.

 Kobayashi M, Deguchi Y, Nozaki Y, Higami Y.

 Int J Mol Sci. 2021 Jun 2;22(11):6025. doi: 10.3390/ijms22116025.(IF: 4.602 in 2020)

・Mitochondrial Unfolded Protein Responses in White Adipose Tissue: Lipoatrophy, Whole-Body Metabolism and Lifespan.

 Kobayashi M, Nezu Y, Tagawa R, Higami Y.

 Int J Mol Sci. 2021 Mar 11;22(6):2854. doi: 10.3390/ijms22062854.(IF: 4.602 in 2020)

Research about Obesity and/or Autophagy

・Long-Term Dietary Taurine Lowers Plasma Levels of Cholesterol and Bile Acids

 Tagawa, R., Kobayashi, M., Sakurai, M., Yoshida, M., Kaneko, H., Mizunoe, Y.Nozaki, Y., Okita, N., Sudo, Y. & Higami, Y.

 Int J Mol Sci. 2022 Feb ,23 (3) 1793.  doi: 10.3390/ijms23031793 (IF: 5.542 (2021/22)

・Trehalose induces SQSTM1/p62 expression and enhances lysosomal activity and antioxidative capacity in adipocytes.

 Kobayashi M, Yasukawa H, Arikawa T, Deguchi Y, Mizushima N, Sakurai M, Onishi S, Tagawa R, Sudo Y, Okita N, Higashi K, Higami Y.

 FEBS Open Bio. 2021 Jan;11(1):185-194. doi: 10.1002/2211-5463.13055. (IF: 2.231 in 2019/20)

2020

Research about Caloric Restriction, mitochondria and/or Aging

・Srebp-1c/Fgf21/Pgc-1α axis regulated by leptin signaling in adipocytes – possible mechanism of caloric restriction-associated metabolic 

   remodeling of white adipose tissue.

 Kobayashi M, Uta S, Otsubo M, Deguchi Y, Tagawa R, Mizunoe Y, Nakagawa Y, Shimano H, Yoshikazu Higami Y, Nutrients. 2020 Jul  10;12(7):E2054. doi: 10.3390/nu12072054.(IF: 4.210 in 2019/20)

・[Metabolic Alteration in Aging Process: Metabolic Remodeling in White Adipose Tissue by Caloric Restriction].

 Kobayashi M, Higami Y.

 Yakugaku Zasshi. 2020;140(3):383-389. doi: 10.1248/yakushi.19-00193-2. Japanese.

・[Multidisciplinary Approach to Aging: Future Trends].

 Takahashi R, Higami Y.

 Yakugaku Zasshi. 2020;140(3):377-378. doi: 10.1248/yakushi.19-00193-F. Japanese. No abstract available.

Research about Obesity and/or Autophagy

 

・WWP1 knockout in mice exacerbates obesity-related phenotypes in white adipose tissue but improves whole-body glucose metabolism.

 Hoshino S, Kobayashi M, Tagawa R, Konno R, Abe T, Furuya K, Miura K, Wakasawa H, Okita N, Sudo Y, Mizunoe Y, Nakagawa Y,

 Nakamura T, Kawabe H, Higami Y.

 FEBS Open Bio. 2020 Mar;10(3):306-315. doi: 10.1002/2211-5463.12795. Epub 2020 Feb(IF: 2.020 in 2019/20)

・Cathepsin B overexpression induces degradation of perilipin 1 to cause lipid metabolism dysfunction in adipocytes.

 Mizunoe Y, Kobayashi M, Hoshino S, Tagawa R, Itagawa R, Hoshino A, Okita N, Sudo Y, Nakagawa Y, Shimano H, Higami Y.

 Sci Rep. 2020 Jan 20;10(1):634. doi: 10.1038/s41598-020-57428-6.(IF: 4.011 in 2019/20)

. Trehalose induces SQSTM1/p62 expression and enhances lysosomal activity and antioxidative capacity in adipocytes.

 Kobayashi M, Yasukawa H, Arikawa T, Deguchi Y, Mizushima N, Sakurai M, Onishi S, Tagawa R, Sudo Y, Okita N, Higashi K, Higami Y*

 FEBS Open Bio. 11(1):185-94, 2020 (IF:2.020 in 2019/20).

2019

Research about Caloric Restriction, mitochondria and/or Aging

・Impact of aging and caloric restriction on fibroblast growth factor 21 signaling in rat white adipose tissue.

 Fujii N, Uta S, Kobayashi M, Sato T, Okita N, Higami Y.

 Exp Gerontol. 2019 Jan 5;118:55-64. doi: 10.1016/j.exger.2019.01.001.(IF: 3.080 in 2018/19)

Research about Obesity and/or Autophagy

 

・Association between Lysosomal Dysfunction and Obesity-Related Pathology: A Key Knowledge to Prevent Metabolic Syndrome.

 Mizunoe Y, Kobayashi M, Tagawa R, Nakagawa Y, Shimano H, Higami Y.

 Int J Mol Sci. 2019 Jul 27;20(15). pii: E3688. doi: 10.3390/ijms20153688. Review. (IF: 4.210 in 2019/20)

・Identification of WWP1 as an obesity-associated E3 ubiquitin ligase with a protective role against oxidative stress in adipocytes.

 Kobayashi M, Hoshino S, Abe T, Okita N, Tagawa R, Nagai W, Konno R, Suzuki Y, Furuya K, Ishikawa N, Okado H, Oku M, Iwamoto M,

 Miura Y, Sudo Y, Higami Y.

 Biochem Biophys Res Commun. 2019 Jan 1;508(1):117-122. doi: 10.1016/j.bbrc.2018.11.127.(IF: 2.559 in 2018)

2018

Research about Caloric Restriction, mitochondria and/or Aging

・Mechanisms of the anti-aging and prolongevity effects of caloric restriction: evidence from studies of genetically modified animals.

 Hoshino S, Kobayashi M, Higami Y*.

 Aging (Albany NY). 10(9):2243-2251, 2018 (IF:5.179 in 2018)

Research about Obesity and/or Autophagy

・Trehalose protects against oxidative stress by regulating the Keap1-Nrf2 and autophagy pathways.

 Mizunoe Y, Kobayashi M, Sudo Y, Watanabe S, Yasukawa H, Natori D, Hoshino A, Negishi A, Okita N, Komatsu M, Higami Y*.

 Redox Biol. 15:115-124, 2018 (IF: 8.023 in 2018)

2017

Research about Caloric Restriction, mitochondria and/or Aging

 

・Mitochondrial intermediate peptidase is a novel regulator of sirtuin-3 activation by caloric restriction.

 Kobayashi M, Takeda K, Narita T, Nagai K, Okita N, Sudo Y, Miura Y, Tsumoto H, Nakagawa Y, Shimano H, Higami Y*.

 FEBS Lett. 591(24):4067-4073, 2017. (IF: 3.00 in 2017)

 

・Sterol regulatory element-binding protein-1c orchestrates metabolic remodeling of white adipose tissue by caloric restriction.

 Fujii N, Narita T, Okita N, Kobayashi M, Furuta Y, Chujo Y, Sakai M, Yamada A, Takeda K, Konishi T, Sudo Y, Shimokawa I, Higami Y*.

 Aging Cell. 16(3):508-517, 2017. (IF: 7.63 in 2017)

Research about Obesity and/or Autophagy

・Involvement of lysosomal dysfunction in autophagosome accumulation and early pathologies in adipose tissue of obese mice.

 Mizunoe Y, Sudo Y, Okita N, Hiraoka H, Mikami K, Narahara T, Negishi A, Yoshida M, Higashibata R, Watanabe S, Kaneko H, Natori D,

 Furuichi T, Yasukawa H, Kobayashi M, Higami Y*.

 Autophagy. 13(4):642-653, 2017. (IF: 11.10 in 2017)