論文一覧
2025
2024
〇The effects of WWP1 overexpression on the golgi apparatus stress response and proteoglycan production in
adipocytes.
Nozaki Y, Suwa F, Furuya K, Komeno M, Hoshino S, Mizunoe Y, Higashi K, Kobayashi M, Higami Y.
Sci Rep. 14 (1), 29004 (2024) DOI:10.1038/s41598-024-79114-7
〇ハイパーサーミアに向けた肝臓等価ファントムの温度特性に関する検討
竹田 昂平、野崎 優香、山本 隆彦
日本AEM学会誌 32(3), 552-556 (2024)
〇カロリー制限下におけるSREBP-1cの発現制御機構と白色脂肪組織の代謝リプログラミング
野崎優香、水之江雄平、樋上賀一
週刊医学のあゆみ特集「脂質制御因子SREBPの新展開」 291 (11), 1028-1032 (2024)
〇脂肪組織による老化・寿命制御
福王智康、野崎優香、水之江雄平、樋上賀一
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN 2024 144 (4). 411-417 doi:10.1248/yakushi.23-00165-4
2023
〇Obesity-induced PARIS (ZNF746) accumulation in adipose progenitor cells leads to attenuated mitochondrial
biogenesis and impaired adipogenesis
Hachiya K, Deguchi Y, Hirata T, Arikawa T, Fukai H, Esashi T, Nagasawa K, Mizunoe Y, Nozaki Y, Kobayashi M, Higami Y.
Sci Rep. 2023 Dec 27;13(1):22990. doi: 10.1038/s41598-023-49996-0.
〇Effect of mitochondrial quantity and quality controls in white adipose tissue on healthy lifespan: Essential roles
of GH/IGF‐1‐independent pathways in caloric restriction‐mediated metabolic remodeling
Otani Y, Nozaki Y, Mizunoe Y, Kobayashi M, Higami Y.
Pathol Int. 2023 Oct;73(10):479-489. doi: 10.1111/pin13371.
〇Systemic depletion of WWP1 improves insulin sensitivity and lowers triglyceride content in the liver of obese
mice.
Nozaki Y, Kobayashi M, Wakasawa H, Hoshino S, Suwa F, Ose Y, Tagawa R, Higami Y.
FEBS Open Bio. 2023 Jun;13(6):1086-1094. doi: 10.1002/2211-5463.13610. Epub 2023 Apr 20. PMID: 37032433.
2022
〇Individual evaluation of aging- and caloric restriction-related changes to distinct multimeric complexes of
circulating adiponectin by immunoblotting.
Kobayashi M, Nezu Y, Itoh M, Uchida R, Arikawa T, Otsubo M, Nozaki Y, Tagawa R, Fujishima Y, Maeda N, Shimomura I, Higami Y.
Exp Gerontol. 2022 Jul;164:111821. doi: 10.1016/j.exger.2022.111821. Epub 2022 Apr 30. PMID: 35504483.
〇Long-term dietary taurine lowers plasma levels of cholesterol and bile acids.
Tagawa R, Kobayashi M, Sakurai M, Yoshida M, Kaneko H, Mizunoe Y, Nozaki Y, Okita N, Sudo Y, Higami Y.
Int J Mol Sci. 2022 Feb 4;23(3):1793. doi: 10.3390/ijms23031793. PMID: 35163722.
〇Intravenous administration of human mesenchymal stem cells derived from adipose tissue and umbilical cord
improves neuropathic pain via suppression of neuronal damage and anti-inflammatory actions in rats.
Miyano K, Ikehata M, Ohshima K, Yoshida Y, Nose Y, Yoshihara SI, Oki K, Shiraishi S, Uzu M, Nonaka M, Higami Y,
Uezono Y.
PLoS One. 2022 Feb 14;17(2):e0262892. doi: 10.1371/journal.pone.0262892. eCollection 2022. PMID: 35157707.
〇Anticancer agent α-sulfoquinovosyl-acylpropanediol enhances the radiosensitivity of human malignant
mesothelioma in nude mouse models.
Inamasu E, Tsuchiya T, Yamauchi M, Nishi K, Matsuda K, Sugawara F, Sakaguchi K, Mori R, Matsumoto K, Miyazaki T,
Hatachi G, Doi R, Watanabe H, Tomoshige K, Matsuda N, Higami Y, Shimokawa I, Nakashima M, Nagayasu T. J
Radiat Res. 2022 Jan 20;63(1):19-29. doi: 10.1093/jrr/rrab090. PMID: 34738103.
2021
〇Oxytocin Is a positive allosteric modulator of κ-Opioid receptors but not δ-Opioid receptors in the G protein
signaling pathway.
Miyano K, Yoshida Y, Hirayama S, Takahashi H, Ono H, Meguro Y, Manabe S, Komatsu A, Nonaka M, Mizuguchi T, Fujii H,
Higami Y, Narita M, Uezono Y.
Cells. 2021 Oct 4;10(10):2651. doi: 10.3390/cells10102651. PMID: 34685631.
〇Induction of cellular senescence in fibroblasts through β1-integrin activation by tenascin-C-derived peptide and
its protumor effect.
Fujita M, Sasada M, Eguchi M, Iyoda T, Okuyama S, Osawa T, Tsuzuranuki K, Sakamoto M, Hagihara Y, Matsumura M,
Osada S, Kodama H, Higami Y, Fukai F.
Am J Cancer Res. 2021 Sep 15;11(9):4364-4379. eCollection 2021. PMID: 34659892.
〇Prolonged caloric restriction ameliorates age-related atrophy in slow and fast muscle fibers of rat soleus
muscle.
Mizunoe Y, Kobayashi M, Saito H, Goto A, Migitaka R, Miura K, Okita N, Sudo Y, Tagawa R, Yoshida M, Umemori A,
Nakagawa Y, Shimano H, Higami Y.
Exp Gerontol. 2021 Oct 15;154:111519. doi: 10.1016/j.exger.2021.111519. Epub 2021 Aug 17. PMID: 34416335.
〇Contribution of PGC-1α to obesity- and caloric restriction-related physiological changes in white adipose tissue.
Kobayashi M, Deguchi Y, Nozaki Y, Higami Y.
Int J Mol Sci. 2021 Jun 2;22(11):6025. doi: 10.3390/ijms22116025. PMID: 34199596. Review.
〇Mitochondrial unfolded protein responses in white adipose tissue: lipoatrophy, whole-body metabolism and
lifespan.
Kobayashi M, Nezu Y, Tagawa R, Higami Y.
Int J Mol Sci. 2021 Mar 11;22(6):2854. doi: 10.3390/ijms22062854. PMID: 33799894. Review.
〇Exposure of the cryptic de-adhesive site FNIII14 in fibronectin molecule and its binding to membrane-type
eEF1A induce migration and invasion of cancer cells via β1-integrin inactivation.
Itagaki K, Sasada M, Miyazaki S, Iyoda T, Imaizumi T, Haga M, Kuga A, Inomata H, Kondo Y, Osada S, Kodama H,
Higami Y, Fukai F.
Am J Cancer Res. 2020 Nov 1;10(11):3990-4004. eCollection 2020. PMID: 33294281.
〇Trehalose induces SQSTM1/p62 expression and enhances lysosomal activity and antioxidative capacity in
adipocytes.
Kobayashi M, Yasukawa H, Arikawa T, Deguchi Y, Mizushima N, Sakurai M, Onishi S, Tagawa R, Sudo Y, Okita N,
Higashi K, Higami Y.
FEBS Open Bio. 2021 Jan;11(1):185-194. doi: 10.1002/2211-5463.13055. Epub 2020 Dec 13. PMID: 33277792.
2020
〇Noninvasive and safe cell viability assay for breast cancer mcf-7 cells using natural food pigment.
Yamashita K, Tagawa R, Higami Y, Tokunaga E.
Biology (Basel). 2020 Aug 14;9(8):227. doi: 10.3390/biology9080227. PMID: 32823990.
〇Srebp-1c/Fgf21/Pgc-1α axis regulated by leptin signaling in adipocytes-possible mechanism of caloric
restriction-associated metabolic remodeling of white adipose tissue.
Kobayashi M, Uta S, Otsubo M, Deguchi Y, Tagawa R, Mizunoe Y, Nakagawa Y, Shimano H, Higami Y.
Nutrients. 2020 Jul 10;12(7):2054. doi: 10.3390/nu12072054. PMID: 32664386.
〇A novel method for evaluating activity of transient receptor potential channels using a cellular dielectric
spectroscopy.
Miyano K, Ohbuchi K, Sudo Y, Minami K, Yokoyama T, Yamamoto M, Uzu M, Nonaka M, Shiraishi S, Murata H, Higami Y,
Uezono Y.
J Pharmacol Sci. 2020 Aug;143(4):320-324. doi: 10.1016/j.jphs.2020.05.001. Epub 2020 May 11. PMID: 32505645.
〇Hyperglycemia contributes to the development of Leydig cell hyperplasia in male Spontaneously Diabetic Torii
rats.
Nakane Y, Kemmochi Y, Ogawa N, Sasase T, Ohta T, Higami Y, Fukai F.
J Toxicol Pathol. 2020 Apr;33(2):121-129. doi: 10.1293/tox.2019-0088. Epub 2020 Mar 20. PMID: 32425345.
〇Nutlin-3a suppresses poly (ADP-ribose) polymerase 1 by mechanisms different from conventional PARP1
suppressors in a human breast cancer cell line.
Kobayashi M, Ishizaki Y, Owaki M, Matsumoto Y, Kakiyama Y, Hoshino S, Tagawa R, Sudo Y, Okita N, Akimoto K, Higami Y. Oncotarget. 2020 May 5;11(18):1653-1665. doi: 10.18632/oncotarget.27581. eCollection 2020 May 5.
PMID: 32405340.
〇Japanese herbal medicine Ninjinyoeito mediates its orexigenic properties partially by activating Orexin 1
receptors.
Miyano K, Ohshima K, Suzuki N, Furuya S, Yoshida Y, Nonaka M, Higami Y, Yoshizawa K, Fujii H, Uezono Y.
Front Nutr. 2020 Feb 27;7:5. doi: 10.3389/fnut.2020.00005. eCollection 2020. PMID: 32175325.
〇[Metabolic alteration in aging process: metabolic remodeling in white adipose tissue by caloric restriction].
Kobayashi M, Higami Y.
Yakugaku Zasshi. 2020;140(3):383-389. doi: 10.1248/yakushi.19-00193-2. PMID: 32115557. Review. Japanese.
〇[Multidisciplinary Approach to Aging: Future Trends].
Takahashi R, Higami Y.
Yakugaku Zasshi. 2020;140(3):377-378. doi: 10.1248/yakushi.19-00193-F. PMID: 32115555. Japanese.
No abstract available.
〇WWP1 knockout in mice exacerbates obesity-related phenotypes in white adipose tissue but improves whole-
body glucose metabolism.
Hoshino S, Kobayashi M, Tagawa R, Konno R, Abe T, Furuya K, Miura K, Wakasawa H, Okita N, Sudo Y, Mizunoe Y,
Nakagawa Y, Nakamura T, Kawabe H, Higami Y.
FEBS Open Bio. 2020 Mar;10(3):306-315. doi: 10.1002/2211-5463.12795. Epub 2020 Feb 3. PMID: 31965758.
〇The radical scavenger NZ-419 suppresses intestinal polyp development in Apc-mutant mice.
Kurokawa Y, Fujii G, Tomono S, Miyamoto S, Hamoya T, Takahashi M, Narita T, Komiya M, Kobayashi M, Higami Y,
Mutoh M. J Clin Med. 2020 Jan 18;9(1):270. doi: 10.3390/jcm9010270. PMID: 31963747.
〇Cathepsin B overexpression induces degradation of perilipin 1 to cause lipid metabolism dysfunction in
adipocytes.
Mizunoe Y, Kobayashi M, Hoshino S, Tagawa R, Itagawa R, Hoshino A, Okita N, Sudo Y, Nakagawa Y, Shimano H,
Higami Y.
Sci Rep. 2020 Jan 20;10(1):634. doi: 10.1038/s41598-020-57428-6. PMID: 31959889.
〇The Japanese herbal medicine Hangeshashinto enhances oral keratinocyte migration to facilitate healing of
chemotherapy-induced oral ulcerative mucositis.
Miyano K, Eto M, Hitomi S, Matsumoto T, Hasegawa S, Hirano A, Nagabuchi K, Asai N, Uzu M, Nonaka M, Omiya Y,
Kaneko A, Ono K, Fujii H, Higami Y, Kono T, Uezono Y.
Sci Rep. 2020 Jan 17;10(1):625. doi: 10.1038/s41598-019-57192-2. PMID: 31953420.
2019
〇Association between lysosomal dysfunction and obesity-related pathology: A key knowledge to prevent
metabolic syndrome.
Mizunoe Y, Kobayashi M, Tagawa R, Nakagawa Y, Shimano H, Higami Y.
Int J Mol Sci. 2019 Jul 27;20(15):3688. doi: 10.3390/ijms20153688. PMID: 31357643. Review.
〇Carboplatin enhances the activity of human transient receptor potential Ankyrin 1 through the cyclic AMP-
protein kinase A-A-kinase anchoring protein (AKAP) pathways.
Miyano K, Shiraishi S, Minami K, Sudo Y, Suzuki M, Yokoyama T, Terawaki K, Nonaka M, Murata H, Higami Y, Uezono Y.
Int J Mol Sci. 2019 Jul 3;20(13):3271. doi: 10.3390/ijms20133271. PMID: 31277262.
〇Alteration of the extracellular matrix and alpha-gal antigens in the rat lung scaffold reseeded using human
vascular and adipogenic stromal cells.
Hashimoto Y, Tsuchiya T, Doi R, Matsumoto K, Higami Y, Kobayashi E, Nagayasu T. J
Tissue Eng Regen Med. 2019 Nov;13(11):2067-2076. doi: 10.1002/term.2923. Epub 2019 Oct 23. PMID: 31267683.
〇Acyclic retinoid combined with tenascin-c-derived peptide reduces the malignant phenotype of neuroblastoma cells through N-Myc degradation.
Otsuka K, Sasada M, Hirano YU, Nohara Y, Iyoda T, Higami Y, Kodama H, Fukai F.
Anticancer Res. 2019 Jul;39(7):3487-3492. doi: 10.21873/anticanres.13494. PMID: 31262872.
〇Combining peptide TNIIIA2 with all-trans retinoic acid accelerates N-Myc protein degradation and neuronal
differentiation in MYCN-amplified neuroblastoma cells.
Otsuka K, Sasada M, Iyoda T, Nohara Y, Sakai S, Asayama T, Suenaga Y, Yokoi S, Higami Y, Kodama H, Fukai F.
Am J Cancer Res. 2019 Feb 1;9(2):434-448. eCollection 2019. PMID: 30906641.
〇Impact of aging and caloric restriction on fibroblast growth factor 21 signaling in rat white adipose tissue.
Fujii N, Uta S, Kobayashi M, Sato T, Okita N, Higami Y.
Exp Gerontol. 2019 Apr;118:55-64. doi: 10.1016/j.exger.2019.01.001. Epub 2019 Jan 5. PMID: 30620889.
〇Differential metabolic responses to adipose atrophy associated with cancer cachexia and caloric restriction in
rats and the effect of rikkunshito in cancer cachexia.
Sudo Y, Otsuka H, Miyakawa R, Goto A, Kashiwase Y, Terawaki K, Miyano K, Hirao Y, Taki K, Tagawa R, Kobayashi M,
Okita N, Uezono Y, Higami Y.
Int J Mol Sci. 2018 Dec 3;19(12):3852. doi: 10.3390/ijms19123852. PMID: 30513935.
〇Identification of WWP1 as an obesity-associated E3 ubiquitin ligase with a protective role against oxidative
stress in adipocytes.
Kobayashi M, Hoshino S, Abe T, Okita N, Tagawa R, Nagai W, Konno R, Suzuki Y, Furuya K, Ishikawa N, Okado H, Oku M,
Iwamoto M, Miura Y, Sudo Y, Higami Y.
Biochem Biophys Res Commun. 2019 Jan 1;508(1):117-122. doi: 10.1016/j.bbrc.2018.11.127. Epub 2018 Nov 22.
PMID: 30471861.
2018
〇Leukemia inhibitory factor via the Toll-like receptor 5 signaling pathway involves aggravation of cachexia
induced by human gastric cancer-derived 85As2 cells in rats.
Terawaki K, Kashiwase Y, Uzu M, Nonaka M, Sawada Y, Miyano K, Higami Y, Yanagihara K, Yamamoto M, Uezono Y. Oncotarget. 2018 Oct 5;9(78):34748-34764. doi: 10.18632/oncotarget.26190. eCollection 2018 Oct 5.
PMID: 30410674.
〇SREBP-1c-dependent metabolic remodeling of white adipose tissue by caloric restriction.
Kobayashi M, Fujii N, Narita T, Higami Y. Int J Mol Sci. 2018 Oct 26;19(11):3335. doi: 10.3390/ijms19113335.
PMID: 30373107. Review.
〇Mechanisms of the anti-aging and prolongevity effects of caloric restriction: evidence from studies of
genetically modified animals.
Hoshino S, Kobayashi M, Higami Y.
Aging (Albany NY). 2018 Sep 16;10(9):2243-2251. doi: 10.18632/aging.101557. PMID: 30222593. Review.
〇Transgenic mice overexpressing SREBP-1a in male ob/ob mice exhibit lipodystrophy and exacerbate insulin
resistance.
Ohno H, Matsuzaka T, Tang N, Sharma R, Motomura K, Shimura T, Satoh A, Han SI, Takeuchi Y, Aita Y, Iwasaki H,
Yatoh S, Suzuki H, Sekiya M, Nakagawa Y, Sone H, Yahagi N, Yamada N, Higami Y, Shimano H.
Endocrinology. 2018 Jun 1;159(6):2308-2323. doi: 10.1210/en.2017-03179. PMID: 29668871.
〇The DNA methylation profile of liver tumors in C3H mice and identification of differentially methylated regions
involved in the regulation of tumorigenic genes.
Matsushita J, Okamura K, Nakabayashi K, Suzuki T, Horibe Y, Kawai T, Sakurai T, Yamashita S, Higami Y, Ichihara G,
Hata K, Nohara K.
BMC Cancer. 2018 Mar 22;18(1):317. doi: 10.1186/s12885-018-4221-0. PMID: 29566670.
〇Taurine is an amino acid with the ability to activate autophagy in adipocytes.
Kaneko H, Kobayashi M, Mizunoe Y, Yoshida M, Yasukawa H, Hoshino S, Itagawa R, Furuichi T, Okita N, Sudo Y, Imae M,
Higami Y.
Amino Acids. 2018 May;50(5):527-535. doi: 10.1007/s00726-018-2550-6. Epub 2018 Mar 9. PMID: 29523960.
〇Differential response to caloric restriction of retroperitoneal, epididymal, and subcutaneous adipose tissue
depots in rats.
Narita T, Kobayashi M, Itakura K, Itagawa R, Kabaya R, Sudo Y, Okita N, Higami Y.
Exp Gerontol. 2018 Apr;104:127-137. doi: 10.1016/j.exger.2018.01.016. Epub 2018 Feb 2. PMID: 29410017.
〇Trehalose protects against oxidative stress by regulating the Keap1-Nrf2 and autophagy pathways.
Mizunoe Y, Kobayashi M, Sudo Y, Watanabe S, Yasukawa H, Natori D, Hoshino A, Negishi A, Okita N, Komatsu M,
Higami Y.
Redox Biol. 2018 May;15:115-124. doi: 10.1016/j.redox.2017.09.007. Epub 2017 Sep 20. PMID: 29241092.
〇A novel mouse model for tracking the fate of CXCR5-expressing T cells.
Takebe T, Sakamoto K, Higami Y, Harada Y.
Biochem Biophys Res Commun. 2018 Jan 8;495(2):1642-1647. doi: 10.1016/j.bbrc.2017.12.029. Epub 2017 Dec 6.
PMID: 29223395.
2017
〇Mitochondrial intermediate peptidase is a novel regulator of sirtuin-3 activation by caloric restriction.
Kobayashi M, Takeda K, Narita T, Nagai K, Okita N, Sudo Y, Miura Y, Tsumoto H, Nakagawa Y, Shimano H, Higami Y.
FEBS Lett. 2017 Dec;591(24):4067-4073. doi: 10.1002/1873-3468.12914. Epub 2017 Nov 28. PMID: 29151261.
〇A novel caloric restriction mediator.
Kobayashi M, Higami Y.
Aging (Albany NY). 2017 Oct 25;9(10):2012-2013. doi: 10.18632/aging.101311. PMID: 29070730 Free PMC article.
No abstract available.
〇Modified Western blotting for insulin and other diabetes-associated peptide hormones.
Okita N, Higami Y, Fukai F, Kobayashi M, Mitarai M, Sekiya T, Sasaki T.
Sci Rep. 2017 Jul 31;7(1):6949. doi: 10.1038/s41598-017-04456-4. PMID: 28761041.
〇Sterol regulatory element-binding protein-1c orchestrates metabolic remodeling of white adipose tissue by
caloric restriction.
Fujii N, Narita T, Okita N, Kobayashi M, Furuta Y, Chujo Y, Sakai M, Yamada A, Takeda K, Konishi T, Sudo Y, Shimokawa I,
Higami Y.
Aging Cell. 2017 Jun;16(3):508-517. doi: 10.1111/acel.12576. Epub 2017 Mar 3. PMID: 28256090 Free PMC article.
〇Development of ghrelin resistance in a cancer cachexia rat model using human gastric cancer-derived 85As2
cells and the palliative effects of the Kampo medicine rikkunshito on the model.
Terawaki K, Kashiwase Y, Sawada Y, Hashimoto H, Yoshimura M, Ohbuchi K, Sudo Y, Suzuki M, Miyano K, Shiraishi S,
Higami Y, Yanagihara K, Hattori T, Kase Y, Ueta Y, Uezono Y.
PLoS One. 2017 Mar 1;12(3):e0173113. doi: 10.1371/journal.pone.0173113. eCollection 2017. PMID: 28249026.
〇Involvement of lysosomal dysfunction in autophagosome accumulation and early pathologies in adipose tissue
of obese mice.
Mizunoe Y, Sudo Y, Okita N, Hiraoka H, Mikami K, Narahara T, Negishi A, Yoshida M, Higashibata R, Watanabe S,
Kaneko H, Natori D, Furuichi T, Yasukawa H, Kobayashi M, Higami Y.
Autophagy. 2017 Apr 3;13(4):642-653. doi: 10.1080/15548627.2016.1274850. Epub 2017 Jan 25. PMID: 28121218.